"ENOUGH CONCERN EXISTS TO WARRANT A RECONSIDERATION OF THE CARDIOVASCULAR SAFETY OF ALL NSAIDS" SAYS STUDY AUTHOR PROFESSOR JULIA HIPPISLEY-COX. NSAIDs are among the most widely prescribed drugs for rheumatoid arthritis and other inflammatory joint conditions. Their effects are mediated through inhibition of the biosynthesis of prostaglandins. They work by irreversibly blocking cyclooxygenase, the enzyme which catalyses the reactions of arachidonic acid to endoperoxide compounds. The neurological and gastrointestinal side effects of these agents have been reviewed in considerable detail. All of the NSAIDs, with the exception of Cytotec, inhibit prostaglandin El, a local hormone responsible for gastric mucosai cytoprotection. A common side effect from these medications is gastric ulcers. More serious adverse reactions such as blood dyscrasias, kidney damage and cardiovascular effects have been noted. Most physicians rotate among the ten most widely prescribed NSAIDs, as soon as one causes negative side effects. NEW SERRAZYME SERRAPEPTASE, the natural alternative to Non Steroidal Anti Inflammatories.